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Cha­rité - Uni­ver­si­täts­me­di­zin Ber­lin - Char­ité Cam­pus Virchow-Kli­ni­kum

The Char­ité - Uni­ver­si­täts­med­izin Ber­lin is a joint med­ical fac­ulty, which ser­ves both Freie Uni­ver­si­tät Ber­lin and Hum­boldt Uni­ver­si­tät zu Ber­lin. As one of the lar­gest uni­ver­sity hos­pit­als in Europe with an import­ant his­tory, it plays a lead­ing role in rese­arch, teach­ing and clin­ical care. The Char­ité uni­ver­sity hos­pital has also made a name for its­elf as a mod­ern busi­ness with cer­ti­fic­a­tions in the med­ical, clin­ical and man­age­ment fields.

PhD stu­dent (male/female)

Work­ing field:

An adverse in utero envir­on­ment includ­ing chem­ical expos­ure is thought to con­trib­ute to impaired organ mat­ur­a­tion and an increased dis­ease risk later in life. We are inter­ested in per­sist­ent epi­gen­etic modi­fic­a­tions in response to such expos­ures that poten­tially lead to long-term res­pir­at­ory com­plic­a­tions. This PhD pro­ject will com­ple­ment our epi­demi­olo­gical stud­ies by estab­lish­ing and apply­ing in vitro mod­els for dif­fer­ent expos­ure scen­arios.

Your area of respons­ib­il­it­ies:

The job holder will be part of a research group focus­ing on epi­gen­etic modi­fic­a­tions and health effects. In his/her pro­ject the job holder will par­tic­u­larly invest­ig­ate the con­sequences of chem­ical expos­ure and oxid­at­ive stress. He/she will estab­lish lung organoid cul­tures to study expos­ure effects in human adult lung and prim­ing effects of an adverse envir­on­ment dur­ing organ devel­op­ment. Dif­fer­ent molecu­lar bio­lo­gical tech­niques will be applied includ­ing whole genom bisul­fid sequen­cing, pyrosequen­cing and qPCR. Epi­gen­etic stud­ies will be com­ple­men­ted by single cell RNA sequen­cing stud­ies.

Require­ments:

  • mas­ter degree in bio­logy, bio­chem­istry, molecu­lar bio­tech­no­logy or rela­ted dis­cip­lines
  • exper­i­ences with in vitro exper­i­men­tal stud­ies and human cell cul­ture mod­els
  • flu­ent in spo­ken and writ­ten Eng­lish
  • col­lab­or­at­ive skills, enthu­si­asm, will­ing­ness to above-aver­age com­mit­ment

How to ap­ply:

Please send your applic­a­tion quot­ing the ref­er­ence numer to

monique.salzmann@charite.de

DIE CHA­RITÉ – UNI­VER­SITÄTS­ME­DI­ZIN BER­LIN makes its human resour­ces decisi­ons based on sui­ta­bi­lity, com­pe­tence and pro­fes­sio­nal per­for­mance. At the same time, it stri­ves to increase the per­cen­tage of women in man­age­ment posi­ti­ons and takes this into con­si­de­ra­tion where can­di­da­tes are equally qua­li­fied wit­hin the lim­its of what is leg­ally pos­si­ble. App­li­ca­ti­ons from people with a migrant back­ground are also expli­citly wel­come. Severely dis­ab­led app­li­cants are given pre­fe­ren­tial con­si­de­ra­tion in the case of can­di­da­tes with equal qua­li­fi­ca­ti­ons. An exten­ded cer­ti­fi­cate of con­duct must be sub­mit­ted. Any tra­vel expen­ses incur­red can­not be reim­bur­sed.

Data pro­tec­tion notice: Cha­rité points out that per­so­nal data is stored and pro­ces­sed as part of the app­li­ca­tion pro­cess in dif­fe­rent areas of Cha­rité (e.g. fac­ulty, staff com­mit­tee, human resour­ces depart­ment). Fur­ther­more, the data may be trans­fer­red or pro­ces­sed wit­hin the group as well as in loca­ti­ons out­side the group (e.g. aut­ho­ri­ties) to pro­tect legi­ti­mate inte­rests. By app­ly­ing, you agree to our data pro­tec­tion regu­la­ti­ons and terms of use, which you can find here:

https://www.charite.de/service/datenschutz/bewerbungsverfahren/