Blätter-Navigation

Of­f­re 2 sur 422 du 21/04/2018, 00:00

logologo

Tech­ni­sche Uni­ver­si­tät Dres­den - Cen­ter for Mole­cu­lar Bio­en­gi­nee­ring (B CUBE), Chair of Bio­mime­tic Mate­ri­als

The TU Dres­den is one of ele­ven Ger­man uni­ver­si­ties that were iden­ti­fied as an “excel­lence uni­ver­sity”. TUD has about 36.500 stu­dents and almost 5319 employees, 507 pro­fes­sors among them, and, thus, is the lar­gest uni­ver­sity in Sax­ony, today.

Having been com­mit­ted to sci­en­ces and the engi­nee­ring before the reuni­fi­ca­tion of Ger­many, TU Dres­den now is a multi-disci­pline uni­ver­sity, also offe­ring huma­nities and social sci­en­ces as well as medi­cine.

Rese­arch Asso­ciate / PhD Stu­dent / Post­doc

At the Cen­ter for Mole­cu­lar Bio­en­gi­nee­ring (B CUBE), an Insti­tute of the Cen­ter for Mole­cu­lar and Cel­lu­lar Bio­en­gi­nee­ring (CMCB), in the Chair of Bio­mime­tic Mate­ri­als (Prof. Nils Krö­ger and Dr. Nicole Poul­sen, http://www.bcube-dresden.de/researchgroups/kroeger/home/) a posi­tion as
Rese­arch Asso­ciate / PhD Stu­dent / Post­doc is avail­able imme­dia­tely. Sub­ject to per­so­nal qua­li­fi­ca­tion employees are remu­n­e­ra­ted accord­ing to salary group E 13 TV-L 65% (PhD stu­dent) or E 13 TV-L (Post­doc). The posi­tion is initi­ally limi­ted for 3 years (PhD Stu­dent) or 2 years (Post­doc) as part of the DFG pro­ject ‘The Mole­cu­lar Basis of Dia­tom Adhe­sion and Moti­lity’ with the pos­si­bi­lity of exten­sion. The period of employ­ment is gover­ned by the Fixed Term Rese­arch Con­tracts Act (Wis­sen­schafts­zeit­ver­trags­ge­setz - Wiss­ZeitVG). The posi­tion offers the chance to obtain fur­ther aca­de­mic qua­li­fi­ca­tion (e.g. PhD / habi­li­ta­tion the­sis).

Work­ing field:

The suc­cess­ful app­li­cant will work on ‘The Mole­cu­lar Basis of Dia­tom Adhe­sion and Moti­lity’. Dia­toms are a large group of unicel­lu­lar euka­ryotic algae that pos­sess intri­ca­tely nano­pat­ter­ned silica cell walls. They are res­pon­si­ble for about 20% of glo­bal bio­lo­gi­cal car­bon fixa­tion, form a sub­stan­tial basis of the marine food web, and are major cont­ri­bu­tors to cli­mate change pro­ces­ses. Bent­hic, pen­nate dia­toms are well known for their adhe­sion strength to natu­ral and man-made sur­faces for­ming dense brown bio­films on sub­mer­ged sur­faces (bio­fou­ling). The annual cost of ship bio­fou­ling exceeds $150 bil­lion, and thus under­stan­ding the mole­cu­lar mecha­nism of dia­tom adhe­sion will inform the deve­lop­ment of novel ship hull designs with anti-bio­fou­ling pro­per­ties. At the same time, insight into the struc­ture-func­tion rela­ti­ons­hip in dia­tom adhe­si­ves will pave the way for desi­gning bio­mime­tic water com­pa­ti­ble glues for tech­no­lo­gi­cal and medi­cal app­li­ca­ti­ons. Many adhe­sive dia­toms have the ability for rapid gli­ding on under­wa­ter sur­faces that is fue­led by an as yet uncha­rac­te­ri­zed intra­cel­lu­lar actin-myo­sin com­plex. Dia­tom moti­lity is unri­val­led among actin-based moti­lity sys­tems as it is extre­mely fast (25 µm/s) and bi-direc­tio­nal. Inves­ti­ga­ting the mole­cu­lar basis of this pro­cess will the­re­fore lay the ground­work for dis­co­ver­ing new chemo-mecha­ni­cal prin­ci­ples in actin-myo­sin depen­dent cell moti­lity. The main aims of the rese­arch pro­jects are iden­ti­fi­ca­tion and func­tio­nal cha­rac­te­riza­t­ion of pro­te­ins of the machinery that gene­ra­tes the force for dia­tom moti­lity. The pro­ject will uti­lize a variety of tech­ni­ques inclu­ding bio­che­mi­cal, mole­cu­lar gene­tic, and mole­cu­lar cell bio­lo­gi­cal approa­ches.

Require­ments:

uni­ver­sity degree (MSc), and - if app­lica­ble - PhD degree, in bio­che­mis­try, bio­lo­gi­cal che­mis­try, mole­cu­lar bio­tech­no­logy, or rela­ted fields; strong rese­arch expe­ri­ence in pro­tein bio­che­mis­try; excel­lent com­mu­ni­ca­tion skills in Eng­lish as this is the lan­guage at the rese­arch centre.

What we of­fer:

The B CUBE http://www.bcube-dresden.de and its part­ner insti­tu­ti­ons, the Bio­tech­no­logy Centre (BIO­TEC) and the Cen­ter for Rege­ne­ra­tive The­ra­pies Dres­den (CRTD), are equip­ped with state-of-the-art faci­li­ties for Mole­cu­lar Bio­sci­ence rese­arch http://biotp.tudresden.de/biotechnology-platform/. They are part of a rich and col­la­bo­ra­tive envi­ron­ment that inclu­des the School of Sci­ence, the Faculty of Medi­cine, the Max Planck Insti­tute of Mole­cu­lar Cell Bio­logy and Gene­tics (MPI-CBG), and the Leib­niz Insti­tute of Poly­mer Rese­arch Dres­den (IPF).

How to ap­ply:

App­li­ca­ti­ons from women are par­ti­cu­larly wel­come. The same app­lies to people with disa­bi­li­ties. Com­plete app­li­ca­ti­ons (let­ter of moti­va­tion, CV, list of publi­ca­ti­ons, and cer­ti­fi­ca­tes of qua­li­fi­ca­ti­ons) should be sent via the Secu­re­Mail Por­tal of the TU Dres­den https://securemail.tu-dresden.de in a sin­gle pdf-file to nora.froehlich@tu-dresden.de or via post to TU Dres­den, B CUBE, Herrn Prof. Nils Krö­ger, Arnold­str. 18, 01307 Dres­den until 02.05.2018 (stam­ped arri­val date app­lies). Please sub­mit copies only, as your app­li­ca­tion will not be retur­ned to you.