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logologo

Tech­ni­sche Uni­ver­si­tät Dres­den - Cen­ter for Rege­ne­ra­tive The­ra­pies Dres­den, Chair of Mole­cu­lar and Cel­lu­lar Immu­no­logy - focus Immu­nore­gu­la­tion (Prof. Dr. Kars­ten Kret­sch­mer)

The TU Dres­den is one of ele­ven Ger­man uni­ver­si­ties that were iden­ti­fied as an “excel­lence uni­ver­sity”. TUD has about 36.500 stu­dents and almost 5319 employees, 507 pro­fes­sors among them, and, thus, is the lar­gest uni­ver­sity in Sax­ony, today.

Having been com­mit­ted to sci­en­ces and the engi­nee­ring before the reuni­fi­ca­tion of Ger­many, TU Dres­den now is a multi-disci­pline uni­ver­sity, also offe­ring huma­nities and social sci­en­ces as well as medi­cine.

Rese­arch Asso­ciate / Post­doc Posi­tion

(Sub­ject to per­so­nal qua­li­fi­ca­tion employees are remu­n­e­ra­ted accord­ing to
salary group E 13 – E 14 TV-L)
The posi­tion is avail­able star­ting as soon as pos­si­ble. We offer an initial con­tract until 31.12.2018 with the pos­si­bi­lity of exten­sion. The period of employ­ment is gover­ned by the Fixed Term Rese­arch Con­tracts Act (Wis­sen­schafts­zeit­ver­trags­ge­setz - Wiss­ZeitVG). The posi­tion aims at obtai­ning fur­ther aca­de­mic qua­li­fi­ca­tion (e.g. habi­li­ta­tion the­sis).
The rese­arch inte­rests of our group focus on mole­cu­lar and cel­lu­lar pathways that govern the gene­ra­tion, life­style and func­tion of Foxp3+ regu­la­tory T (Treg) cells, which play an essen­tial role in main­tai­ning immune home­o­sta­sis in mice and men. A par­ti­cu­larly striking example of Foxp3+ Treg cell func­tion that restrains destruc­tive tis­sue-spe­ci­fic auto­im­munity is the obser­va­tion that acute Treg cell abla­tion in the NOD mouse model of human type 1 dia­be­tes unleas­hes overt auto­im­mune dia­be­tes wit­hin days (Pet­zold et al., J Dia­be­tes Res 2013). Con­ver­sely, Treg cells repre­sent excit­ing gain-of-func­tion tar­gets in cli­ni­cal set­tings of unwan­ted immune res­pon­ses, such as auto­im­munity, all­er­gies and trans­plant rejec­tion.

Work­ing field:

The posi­tion we offer is part of a pro­ject in which we aim to inves­ti­gate the mole­cu­lar and epi­ge­ne­tic mecha­nisms under­ly­ing the deve­lop­ment and main­ten­ance of Foxp3+ Treg cell sub­li­neages. In this con­text, a par­ti­cu­lar focus is pla­ced on explo­ring the pos­si­bi­lity that dif­fe­rent Treg cell sub­phe­no­ty­pes exert spe­cia­li­zed effec­tor func­tions in the con­trol of unwan­ted immu­nity, such as auto­im­munity (web­page: http://www.crt-dresden.de/research/crtd-core-groups/kretschmer.html).

Require­ments:

We aim at attrac­ting the best talent in the respec­tive rese­arch fields and expect the fol­lo­wing: an uni­ver­sity degree, an out­stan­ding PhD degree (or equi­va­lent) in Bio­logy, Sci­ence or rela­ted field of sci­ence; if app­lica­ble post­doc­to­ral lec­ture qua­li­fi­ca­tion, a habi­li­ta­tion the­sis; expe­ri­ence in immu­no­logy, flow cyto­metry, gene-tar­ge­ted and auto­im­mune mouse models, cell cul­ture and mole­cu­lar/bio­che­mi­cal methods; ability to work in an inter­na­tio­nal team is essen­tial; inter- and mul­ti­di­sci­pli­nary thin­king; high moti­va­tion; an inte­gra­tive and coope­ra­tive per­so­na­lity with excel­lent com­mu­ni­ca­tion and social skills; flu­ency in Eng­lish – writ­ten and oral.

How to ap­ply:

Applic­a­tions from women are par­tic­u­larly wel­come. The same applies to people with dis­ab­il­it­ies.
Applic­a­tion Pro­ced­ure
Your applic­a­tion should include: 1. Cover let­ter, indic­at­ing cur­rent and future research interests and career goals; 2. Descrip­tion of research exper­i­ence and accom­plish­ments, includ­ing sum­mary of pre­vi­ous research done dur­ing your PhD thesis (max. 2 pages); 3. List of pub­lic­a­tions, if applic­able; 3. CV, includ­ing cop­ies of degree cer­ti­fic­ates and tran­script of grades (i.e. the offi­cial list of course­work includ­ing your grades); 4. Two let­ters of recom­mend­a­tion or con­tact inform­a­tion for two ref­er­ences, includ­ing cur­rent super­visor. Please sub­mit your applic­a­tion by 18.10.2017 (stamped arrival date of TU Dresden applies) prefer­ably by email as a single pdf doc­u­ment (using “sur­name_first­name.pdf”) to silvia.palme@tu-dresden.de (Please note: We are cur­rently not able to receive elec­tron­ic­ally signed and encryp­ted data.) or to: TU Dresden, CRTD, Frau Silvia Palme, Fetscher­str. 105, 01307 Dresden, Ger­many. Please sub­mit cop­ies of doc­u­ments only, as your applic­a­tion will not be returned to you. Expenses incurred in attend­ing inter­views can­not be reim­bursed.