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Helm­holtz-Zen­trum Dres­den-Ros­sen­dorf e.V.

As a mem­ber of the Helm­holtz Asso­cia­tion of Ger­man Rese­arch Cen­ters, the HZDR employs about 1,400 people. The Cen­ter's focus is on inter­di­sci­pli­nary rese­arch in the areas energy, health and mat­ter.

At the Insti­tute of Radio­phar­maceu­ti­cal Can­cer Rese­arch sci­en­tists from the fields of phy­sics, che­mi­stry, bio­logy, phar­macy, immu­no­logy, medi­cine and IT deve­lop inno­va­tive radio­phar­maceu­ti­cals and novel tools for func­tio­nal cha­rac­te­ri­za­tion, impro­ved ima­ging and per­so­na­li­zed tre­at­ment of tumors.

As part of the Insti­tute, the Depart­ment of Radi­onu­clide Ther­agnostics invi­tes app­li­ca­ti­ons as Post­Doc (f/m/d) Func­tio­n­a­li­za­tion, radio­la­be­ling and cha­rac­te­ri­za­tion of com­plex pro­tein assem­blies.

The posi­tion will be avail­able from 1 Janu­ary 2022. The employ­ment con­tract is limi­ted to two years.

Post­Doc (f/m/d) Func­tio­n­a­li­za­tion, radio­la­be­ling and cha­rac­te­ri­za­tion of com­plex pro­tein assem­blies

Working field:

The suc­cess­ful can­di­date (f/m/d) will work on an inter­di­sci­pli­nary European pro­ject as part of a well-estab­lished radio­phar­maceu­ti­cal sci­ence rese­arch team and the respon­si­bi­li­ties will include, but are not limi­ted to:

  • Carry out cut­ting-edge rese­arch in the areas of radio­che­mi­stry, bio­logy and bio­che­mi­stry with par­ti­cu­lar focus on the modi­fi­ca­tion and cha­rac­te­ri­za­tion of pro­tein assem­blies and nano­par­ti­cle-pro­tein com­ple­xes
  • Pro­pose, eva­luate, inter­pret and vali­date appro­priate radio­la­be­ling pro­to­cols for com­plex pro­tein assem­blies
  • Inves­ti­gate and eva­luate the sta­bi­lity and func­tio­n­a­lity of radio­la­be­led mole­cu­les in vitro by cell bin­ding and upt­ake stu­dies
  • Per­form expe­ri­ments in a state-of-the-art radio­che­mi­stry labo­ra­tory infra­st­ruc­ture, deploy novel tech­no­lo­gies and col­la­bo­rate with inter­nal and exter­nal part­ners to pro­mote the pro­ject
  • Qua­lity con­trol and quan­ti­fi­ca­tion of radio­con­ju­ga­tes by Radio High Per­for­mance Liquid Chro­ma­to­gra­phy (Radio-HPLC), Radio Thin Layer Chro­ma­to­gra­phy (Radio-TLC) and Size Exclu­sion Chro­ma­to­gra­phy (SEC) in the radio­che­mi­stry lab envi­ron­ment
  • Imple­ment radia­tion safety regu­la­ti­ons (e.g. trai­nings, dosi­me­try, release of radioac­tive waste)
  • Ana­lyze expe­ri­men­tal data and com­mu­ni­cate the results in work in pro­gress reports, inter­na­tio­nal con­fe­ren­ces and publi­ca­ti­ons in aca­de­mic and peer-reviewed jour­nals
  • Super­vise stu­dents and apply for third-party fun­ding

Requirements:

  • PhD degree in Bio­logy, Bio­che­mi­stry, Phar­maceu­ti­cal or Radio­phar­maceu­ti­cal Sci­en­ces or a rela­ted field
  • Prac­ti­cal expe­ri­ence in (Radio-)Bio­logy, (Radio-)Phar­maceu­ti­cal Sci­en­ces as well as bio­con­ju­ga­tion, pro­tein modi­fi­ca­tion and puri­fi­ca­tion
  • Exper­tise in the func­tio­n­a­li­za­tion and radio­la­be­ling of bio­mole­cu­les as well as expe­ri­ence in eva­lua­ting pro­tein-cell inter­ac­tions are desi­ra­ble
  • Hands-on expe­ri­ence with unsea­led radioac­tive sub­s­tan­ces
  • Exten­sive cell cul­ture prac­tice
  • Demons­tra­ted sci­en­ti­fic pro­duc­tivity
  • Excel­lent writ­ten and oral com­mu­ni­ca­tion skills (Eng­lish and Ger­man)
  • Reli­able team player, with very good orga­ni­za­tion skills

What we offer:

  • A vibrant rese­arch com­mu­nity in an open, diverse and inter­na­tio­nal work envi­ron­ment
  • Sci­en­ti­fic excel­lence and exten­sive pro­fes­sio­nal net­wor­king oppor­tu­nities
  • The employ­ment con­tract is limi­ted to two years
  • Salary and social bene­fits in con­for­mity with the pro­vi­si­ons of the Collec­tive Agree­ment TVöD-Bund
  • 30 days of paid holi­day leave
  • Com­pany pen­sion scheme (VBL)

A good work/life balance for which we offer assi­s­tance in the form of:

  • Pos­si­bi­lity to work part-time
  • Fle­xi­ble working hours
  • In-house health manage­ment

How to apply:

Kindly sub­mit your com­ple­ted app­li­ca­tion (inclu­ding cover let­ter, CV, diplo­mas/tran­scripts, etc.) only via our Online-app­li­ca­tion-sys­tem.