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Cha­rité - Uni­ver­si­täts­me­di­zin Ber­lin

The Charité - Universitätsmedizin Berlin is a joint medical faculty, which serves both Freie Universität Berlin and Humboldt Universität zu Berlin. As one of the largest university hospitals in Europe with an important history, it plays a leading role in research, teaching and clinical care. The Charité university hospital has also made a name for itself as a modern business with certifications in the medical, clinical and management fields.

PhD position on "Mechanosensation of Angiogenesis in Bone Healing"

Julius Wolff Institute and Berlin Institute of Health Center for Regenerative Therapies

Work­ing field:

Within the scope of SFB 1444, a PhD position on the role of mechanosensation in angiogenesis during bone healing is available at the Julius Wolff Institute and the Berlin Institute of Health Center for Regenerative Therapies at Charité-Universitätsmedizin Berlin. Self-organisation of vessels is carefully regulated already early in healing and supports a scar-free regeneration. These cascades of angiogenesis are sensitive to internal and external mechanical conditions and steer sprouting of blood vessels and depend on the regulation of proinflammatory vs anti-inflammatory immune balance – however the basic mechanisms of this regulation are not yet understood. Within the framework of this sub-project in the DFG-funded collaborative research center (SFB 1444), the role of inter-cellular communications in angiogensis in successful healing are studied.

This subproject is a partnership with Prof. Holger Gerhard (MDC), who is an expert in angiogenesis and its imaging. You will be in charge of applying a previously developed in vivo imaging technology, which allows longitudinal studies in the fracture zone, to monitor endothelial cells, fibroblasts and immune cells at sub-cellular resolution. The system is a result from the tight cooperation between our group and Prof. Anja Hauser (Charité) and Prof. Raluca Niesner (FU). In these groups, additional PhDs will focus on the role of immune cells and be complemented by your view from a biophysics/mechano-biological view. First, we aim at characterizing the dynamic changes in vessel formation, adaptation and remodelling in the beginning of healing at high resolution. Second, this self-assembly will be analysed in a successful scar-free healing and compared to the principles under scarring conditions. Finally, we aim at using imaging technologies to unravel the role of mechanics in angiogenesis on a cellular level and the underlying mechanism of cellular self-assembly.

Scientific staff is given sufficient time to carry out their own scientific work in accordance with their employment relationship.

Require­ments:

  • Master' degree in biophysics, biotechnology, engineering or life sciences
  • experiences in (biophysics of) imaging of biological tissues would be helpful
  • interest in the biophysics/mechano-biology of extracellular matrix and open to learn more about endothelial and immune cells
  • Ability and enthusiasm to work as a team player in a multidisciplinary, collaborative and international environment
  • Proficiency in written and spoken English
  • Willingness to work with animal (mouse) models