Charité - Universitätsmedizin Berlin - Department of Nephrology and Medical Intensive Care
The Charité - Universitätsmedizin Berlin is a joint medical faculty, which serves both Freie Universität Berlin and Humboldt Universität zu Berlin. As one of the largest university hospitals in Europe with an important history, it plays a leading role in research, teaching and clinical care. The Charité university hospital has also made a name for itself as a modern business with certifications in the medical, clinical and management fields.
Research Associate (Postdoc) - Chronic and genetic kidney disease
The research objective of the workgroup is to better understand and tackle the challenges related to chronic kidney disease (CKD) caused by autosomal polycystic kidney disease (ADPKD) with the ultimate goal of improving patients’ lives. This position offers an innovative, multidisciplinary, and intersectoral workgroup that aims to develop creative solutions for the diagnosis and treatment of ADPKD, the most common monogenetic disease.
Within our autosomal dominant polycystic kidney disease (ADPKD) group we are seeking a postdoctoral candidate for a combined molecular and clinical project entitled "Inducing apoptosis in kidney cysts – A novel approach to curing ADPKD, the most common monogenetic disease".
We offer a challenging translational project in a well-organized, international, and high-profile research environment within the Department of Nephrology and Medical Intensive Care at the Charité in Berlin. Our group has a longstanding history of investigating the (patho)physiology of kidney disease. Building on preliminary findings, we aim to test whether the induction of apoptosis in tubular cells of a PKD1 knockout mouse model attenuates the cystic phenotype and improves kidney function by decreasing the viability of cyst lining cells. Our previous work has shown that cyst lining cells strongly express HIF1α in the context of ADPKD. Because the HIF pathway may be considered a viability factor for cells in a hypoxic environment and therefore is linked with cell death and survival decisions, we will investigate this interface with the ultimate goal of identifying novel upstream and downstream targets to delay the progressive loss of kidney function due to cyst growth. The aim is to selectively induce apoptosis by decreasing cell viability in cyst lining cells and therefore to ameliorate the cystic phenotype in in ADPKD. To this end, a wide variety of cutting-edge techniques will be applied including cellular and molecular biological, biochemical and in vivo (Mus musculus) procedures.
Scientific staff is given sufficient time to carry out their own scientific work in accordance with their employment relationship.
PhD degree in Biology, Biochemistry, Molecular/Cell Biology or related fields
Background knowledge in kidney physiology
Strong interest in translational approaches (from bench to bedside), incl. willingness to carry out animal experimental research, cooperation with academic and industry partners
Strong background and practical experience in in cellular, molecular biological, and biochemical research
Knowledge and practical experience in handling mouse models of kidney disease is advantageous but not essential
Ability to work independently, efficiently and goal-oriented
Supervision of PhD-students and medical doctorate students and technical assistants
Motivated to succeed with a love of learning and a desire to keep challenging yourself
Excellent knowledge of the English language (written and verbal communication), German language skills are a plus, but not essential