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Cha­rité - Uni­ver­si­täts­me­di­zin Ber­lin - Ber­lin Insti­tute of Health (BIH) - Stem Cell Core Facil­ity

The Char­ité - Uni­ver­si­täts­med­izin Ber­lin is a joint med­ical fac­ulty, which ser­ves both Freie Uni­ver­si­tät Ber­lin and Hum­boldt Uni­ver­si­tät zu Ber­lin. As one of the lar­gest uni­ver­sity hos­pit­als in Europe with an import­ant his­tory, it plays a lead­ing role in rese­arch, teach­ing and clin­ical care. The Char­ité uni­ver­sity hos­pital has also made a name for its­elf as a mod­ern busi­ness with cer­ti­fic­a­tions in the med­ical, clin­ical and man­age­ment fields.

Postdoc in stem cell and organoid research

Char­ité Cam­pus Virchow-Klinikum

Work­ing field:

We are look­ing for an enthu­si­astic and out­stand­ing postdoc­toral can­did­ate for a cent­ral tech­no­logy pro­vi­sion pro­ject in the Col­lab­or­at­ive Research Centre/Trans­re­gio 296 Loco­Tact fun­ded by the DFG. The Loco­Tact CRC-TR aims to dis­sect the local con­trol of thyroid hor­mone action in physiology and patho­physiology (https://www.uni-due.de/crctr296/). The inter­dis­cip­lin­ary research con­sor­tium will take advant­age of soph­ist­ic­ated in vitro tools such as 3D organoids derived from human pluri­po­tent stem cells (hPSC) to facil­it­ate the stud­ies on the local con­trol of thyroid hor­mone action in trans­la­tion­ally rel­ev­ant human model sys­tems.

The postdoc will be given suf­fi­cient time for his own sci­entific work in accord­ance with his employ­ment con­tract.

Your area of respons­ib­il­ity:

The can­did­ate will be expec­ted to estab­lish dif­fer­en­ti­ation pro­to­cols based on pub­lished meth­ods and to fur­ther develop and stand­ard­ize them in close col­lab­or­a­tion with indi­vidual con­sor­tium part­ners regard­ing their spe­cific pro­ject needs. Addi­tion­ally, the can­did­ate will set up state-of-the-art meth­ods for ana­lysis of 3D organoids (single cell RNA sequen­cing, 3D high con­tent ima­ging).

Area of work:
  • Use of hPSC to gen­er­ate 2D, 3D and organoid mod­els of the liver, brain and heart.
  • Organoid engin­eer­ing: explore and estab­lish per­fu­sion sys­tems, organoid-on a chip tech­no­logy
  • Genetic engin­eer­ing of hPSC using CRISPR/Cas
  • Mul­ti­di­men­sional micro­scopy, high con­tent micro­scopy and high con­tent ana­lysis.
  • Single cell sequen­cing
  • Teach­ing and super­vi­sion of stu­dents and research­ers apply­ing the estab­lished meth­ods

Require­ments:

We are look­ing for a solu­tion-ori­ented, organ­iz­a­tional and pos­it­ive mind­set and flex­ible per­son­al­ity. The abil­ity to work in a highly col­lab­or­at­ive envir­on­ment both inde­pend­ently and as part of the team is essen­tial.

Can­did­ate require­ments:
  • Gradu­ate degree in Bio­logy, Bio­tech­no­logy, Bio­chem­istry, or sim­ilar and a PhD degree in cell/molecu­lar/devel­op­mental/stem cell bio­logy/ or sim­ilar, with a track-record of suc­cess­ful sci­entific work.
  • strong back­ground in cell and molecu­lar bio­logy. Altern­at­ively, can­did­ates with an engin­eer­ing back­ground applied to cell bio­logy are also encour­age to apply.
  • Excel­lent skills in hand­ling primary cells or stem cells.
  • Exper­i­ence using organoids and/or next-gen­er­a­tion sequen­cing, bioin­form­at­ics or mul­ti­di­men­sional ima­ging are con­sidered an advant­age
  • Excel­lent Eng­lish com­mu­nic­a­tion skills, both oral and writ­ten, are pre­requis­ite for the suc­cess­ful can­did­ate.

How to ap­ply:

The applic­a­tion must include (in pdf format):
  • Motiv­a­tion let­ter (describ­ing the applic­ant long-term research vis­ion and why the applic­ant thinks, is the right one to fill this pos­i­tion).
  • Cur­riculum vitae incl. edu­ca­tion, exper­i­ence, pre­vi­ous employ­ments, lan­guage skills and other rel­ev­ant skills and list of pub­lic­a­tions.
  • List of three ref­er­ences (full address, incl. email and phone num­ber).

Please send all applic­a­tion doc­u­ments, e.g. cover let­ter, cur­riculum vitae, cer­ti­fic­ates, attest­a­tions, etc. to the fol­low­ing address, quot­ing the ref­er­ence num­ber

Char­ité - Uni­versitätsmed­izin Ber­lin
Ber­lin Insti­tute of Health - Stem Cell Core Facil­ity
Harald.Stachelscheid@charite.de

Details of con­tact per­son:

Dr. rer. nat. Har­ald Stachelscheid

DIE CHAR­ITÉ – UNI­VERSITÄTSMED­IZIN BER­LIN makes its human resources decisions based on suit­ab­il­ity, com­pet­ence and pro­fes­sional per­form­ance. At the same time, it strives to increase the per­cent­age of women in man­age­ment pos­i­tions and takes this into con­sid­er­a­tion where can­did­ates are equally qual­i­fied within the lim­its of what is leg­ally pos­sible. Applic­a­tions from people with a migrant back­ground are also expli­citly wel­come. Severely dis­abled applic­ants are given pref­er­en­tial con­sid­er­a­tion in the case of can­did­ates with equal qual­i­fic­a­tions. An exten­ded cer­ti­fic­ate of con­duct must be sub­mit­ted. Any travel expenses incurred can­not be reim­bursed.

Data pro­tec­tion notice: Char­ité points out that per­sonal data is stored and pro­cessed as part of the applic­a­tion pro­cess in dif­fer­ent areas of Char­ité (e.g. fac­ulty, staff com­mit­tee, human resources depart­ment). Fur­ther­more, the data may be trans­ferred or pro­cessed within the group as well as in loc­a­tions out­side the group (e.g. author­it­ies) to pro­tect legit­im­ate interests. By apply­ing, you agree to
our data pro­tec­tion reg­u­la­tions and terms of use, which you can find here https://www.charite.de/service/datenschutz/bewerbungsverfahren/.