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Cha­rité-Uni­ver­si­täts­me­di­zin Ber­lin - Ber­lin-Bran­den­burg Cen­ter for Rege­ne­ra­tive The­ra­pies

Das BCRT wurde 2006 als Alli­anz der Cha­rité-Uni­ver­si­täts­me­di­zin Ber­lin und der Helm­holtz-Gemein­schaft gegrün­det. Mehr als 250 Mit­ar­bei­ter – Ärzte, Natur­wis­sen­schaft­ler, Trans­la­ti­ons­ex­per­ten, Inge­nieure, Dok­to­ran­den und tech­ni­sche Mit­ar­bei­ter – for­schen und arbei­ten an den zwei Stand­or­ten des BCRT: am Insti­tuts­ge­bäude Süd des Cam­pus Vir­chow-Kli­ni­kum der Cha­rité und am Cam­pus Tel­tow des Insti­tuts für Bio­ma­te­ri­al­for­schung der Helm­holtz-Zen­trums Geest­hacht GmbH.

BACH­ELOR THESIS PRO­POSAL

Mul­timodal ima­ging of cor­tical bone poros­ity of the human femoral neck.

Work­ing field:

DESCRIP­TION: Bio­med­ical ima­ging of 3D bone struc­tures has received increased atten­tion due to its poten­tial for the under­stand­ing and dia­gnosis of human bone fra­gil­ity. A num­ber of new ima­ging mod­al­it­ies have been intro­duced in recent years, each of these reveal­ing dif­fer­ent prop­er­ties of the same mater­ial. 3D High-res­ol­u­tion com­puted tomo­graphy (CT) images (fig­ure LEFT) are becom­ing avail­able to clini­cians and bio­med­ical research­ers for the assess­ment of bone strength. However, micro­struc­tural para­meter such as bone poros­ity (fig­ure RIGHT) play a role in the bone frac­ture mech­an­isms and remain bey­ond the limit res­ol­u­tion of CT scans.

Require­ments:

Within this thesis, we aim at ima­ging the cor­tical bone poros­ity of the femoral neck, being this the most import­ant frac­ture site in the eld­erly pop­u­la­tion. The stu­dent will per­form Scan­ning Acous­tic Micro­scopy scans of human hip samples and com­bine these with already avail­able CT acquis­i­tions. We will learn together the basic con­cepts of bio­med­ical 2D and 3D ima­ging and apply these to char­ac­ter­ize some of the struc­tural prop­er­ties of cor­tical bone.

REQUIRE­MENTS: No pre­vi­ous know­ledge is needed for this thesis but you should feel motiv­ated to learn about the mar­vel of bone.

What we of­fer:

To work in an inter­na­tional and inter­dis­cip­lin­ary research Envir­on­ment.

How to ap­ply:

Send your applic­a­tion and CV by email.