Blätter-Navigation

Of­fer 209 out of 350 from 31/07/17, 09:36

logo

Robert Koch-Insti­tut - FG16 - Para­sit­o­logy

The Robert Koch Insti­tute in Ber­lin is the fed­eral pub­lic health insti­tute of Ger­many and a lead­ing research insti­tute on infec­tious dis­eases, includ­ing human para­sites (www.rki.de).

PhD pos­i­tion in molecu­lar bio­logy /para­sit­o­logy

part of the Inter­na­tional Research Train­ing Pro­gram (IRTG 2290) "Cross­ing bound­ar­ies - molecu­lar inter­ac­tions in mal­aria" at the Robert Koch Insti­tute in Ber­lin

Work­ing field:

Pro­ject descrip­tion:
The api­co­plast is an essen­tial plastid-like organ­elle of Plas­modium spp. and the related Tox­o­plasma gondii para­site. Its ferredoxin (Fd) redox sys­tem plays a cent­ral meta­bolic role as elec­tron donor to enzymes via pro­tein-pro­tein inter­ac­tions (PPI). The aim of the pro­ject is to study Fd’s PPIs to dis­sect its meta­bolic roles in the api­co­plast and to elu­cid­ate in Plas­modium the role of repor­ted Fd muta­tions in artemisinin res­ist­ance. These will be approached by genetic screens in E. coli for PPI inhib­it­ors (i.e. cyc­lic pep­tide ‘dis­so­ci­at­ors’; Curr. Opin. Chem. Biol. 38, 30–35 (2017)) and their sub­sequent bio­phys­ical and in situ val­id­a­tion in the para­site on Fd’s func­tion. These stud­ies will be com­ple­men­ted with Fd gene knock-out in Plas­modium and assess­ment of artemisinin res­ist­ance with com­ple­men­ted mutants. For more inform­a­tion visit https://www.allianceberlincanberra.org/application-1/project-seeber/.

Require­ments:

You should ideally have a pro­found the­or­et­ical as well as exper­i­mental back­ground in molecu­lar bio­logy and/or bio­chem­istry and tech­niques like DNA clon­ing, lib­rary con­struc­tions, cell trans­fec­tions and/or pro­tein ana­lysis tech­niques. Sub­stan­tial interests in bio­chem­ical ques­tions paired with a strong ambi­tion for innov­at­ive ideas are per­fect matches to make this inter­est­ing pro­ject a suc­cess.
Pro­fi­ciency in Eng­lish is man­dat­ory since the research pro­ject will involve work car­ried out in both Ber­lin and Can­berra, with a one year stay in the part­ner labs at the Aus­tralian National Uni­versity (ANU).

What we of­fer:

A PhD pos­i­tion for 3 years (TV-L E13 (65%) within the newly estab­lished DFG-fun­ded Inter­na­tional Research Train­ing Pro­gram 2290 “Cross­ing bound­ar­ies - molecu­lar inter­ac­tions in mal­aria” (https://www.allianceberlincanberra.org/). PhD stu­dents will gradu­ate with a dual PhD from both the Hum­boldt Uni­versity and the Aus­tralian National Uni­versity (ANU).

How to ap­ply:

Send your applic­a­tion dir­ectly as PDFs to Frank See­ber. Details for applic­a­tion can be found at https://www.allianceberlincanberra.org/application-1/general-information/. Note that for apply­ing to this par­tic­u­lar pro­ject (B6) the dead­line has been exten­ded to August 13th 2017.