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Tech­ni­sche Uni­ver­si­tät Dres­den - Cen­ter for Mole­cu­lar and Cel­lu­lar Bio­en­gi­nee­ring (CMCB), Bio­tech­no­logy Cen­ter (BIO­TEC), Rese­arch Group Bio­me­di­cal Geno­mics

Tech­ni­sche Uni­ver­si­tät Dres­den (TUD), as a Uni­ver­sity of Excel­lence, is one of the lea­ding and most dyna­mic rese­arch insti­tu­ti­ons in the coun­try. Foun­ded in 1828, today it is a glo­bally ori­en­ted, regio­nally ancho­red top uni­ver­sity as it focu­ses on the grand chal­len­ges of the 21st cen­tury. lt deve­lops inno­va­tive solu­ti­ons for the world's most pres­sing issues. In rese­arch and aca­de­mic pro­grams, the uni­ver­sity unites the natu­ral and engi­nee­ring sci­en­ces with the huma­nities, social sci­en­ces and medi­cine. This wide range of disci­pli­nes is a spe­cial fea­ture, faci­li­ta­ting inter­di­sci­pli­na­rity and trans­fer of sci­ence to society. As a modern employer, it offers attrac­tive working con­di­ti­ons to all employees in tea­ching, rese­arch, tech­no­logy and admi­nis­tra­tion. The goal is to pro­mote and deve­lop their indi­vi­dual abi­li­ties while empowering ever­yone to reach their full poten­tial. TUD embo­dies a uni­ver­sity cul­ture that is cha­rac­te­ri­zed by cos­mo­po­li­ta­nism, mutual appre­cia­tion, thri­ving inno­va­tion and active par­ti­ci­pa­tion.

For TUD diver­sity is an essen­tial fea­ture and a qua­lity cri­ter­ion of an excel­lent uni­ver­sity. Accord­in­gly, we wel­come all app­li­cants who would like to com­mit them­sel­ves, their achie­ve­ments and pro­duc­tivity to the suc­cess of the whole insti­tu­tion.

Rese­arch Asso­ciate / Post­doc Com­pu­ta­tio­nal Genome Bio­logy (m/f/x)

English

(sub­ject to per­so­nal qua­li­fi­ca­tion employees are remu­ne­ra­ted accord­ing to salary group E 13 TV-L)

The posi­tion is star­ting as soon as pos­si­ble. The posi­tion with 100% of the full­time wee­kly hours is limi­ted for 3 years. Of these, 35% of the full­time wee­kly hours are sub­ject to avail­able third-party funds from April 1, 2025. The period of employ­ment is gover­ned by the Fixed Term Rese­arch Con­tracts Act (Wis­sen­schafts­zeit­ver­trags­ge­setz-WissZeitVG). The posi­tion offers the chance to obtain fur­ther aca­de­mic qua­li­fi­ca­tion (e.g. habi­li­ta­tion the­sis).

Working field:

3D genome archi­tec­ture plays a major role in genome orga­ni­sa­tion, gene regu­la­tion and genome sta­bi­lity. Thus, dere­gu­la­tion of 3D genome archi­tec­ture is also an important mecha­nism con­tri­bu­ting to disease.
To streng­t­hen our diverse team, we are loo­king for a post­doc­to­ral fel­low to study genome archi­tec­ture as part of the DFG prio­rity pro­gram „Spa­tial Genome Archi­tec­ture in Deve­lop­ment and Disease (Genome3)“. We will par­ti­cu­larly focus on the nuclear pore and how it affects gene regu­la­tion and genome sta­bi­lity in neural deve­lop­ment and brain can­cer. The pro­ject is a col­la­bo­ra­tion bet­ween the lab of Tomo­hisa Toda on „Nuclear archi­tec­ture in neural plasti­city and age­ing“ and the com­pu­ta­tio­nal Rese­arch Group of Anna Poe­tsch on „Bio­me­di­cal Geno­mics“ at the Bio­tech­no­logy Cen­ter of the TU Dres­den, where this posi­tion will be based.
The posi­tion will offer an exci­ting col­la­bo­ra­tive inter­di­sci­pli­nary rese­arch pro­ject embed­ded in a pres­ti­gious rese­arch pro­gram. The suc­cess­ful can­di­date will use methods on multi-omics data ana­ly­sis to inves­ti­gate how 3D genome archi­tec­ture in the nuclear pore affects gene regu­la­tion and genome sta­bi­lity with data on genome archi­tec­ture (e.g. HiC, Hi-ChiP, DamID-HiChiP, MicroC), gene regu­la­tion (e.g. ChiP, DamID-ChiP, ATAC-Seq, RNA-seq), DNA damage (AP-Seq, 8-oxoG, END-Seq), germline muta­ti­ons in neu­ro­de­ve­lop­men­tal dis­or­ders, and soma­tic muta­ti­ons in paediatric brain tumours. Thus, the suc­cess­ful can­di­date will have the oppor­tu­nity to receive trai­ning in cut­ting-edge methods in multi-omics data inte­gra­tion and the pos­si­bi­lity to learn and apply machine lear­ning and deep lear­ning methods on geno­mics data.

Requirements:

  • Excel­lent uni­ver­sity and PhD degree with expe­ri­ence in mole­cu­lar bio­logy, com­pu­ta­tio­nal bio­logy, gene­tics, geno­mics, or equi­va­lent sci­en­ti­fic back­ground with an excel­lent under­stan­ding of genome bio­logy.
  • Com­pre­hen­sive pro­gramming expe­ri­ence in python and/or R.
  • Demons­tra­ble expe­ri­ence in multi-omics data ana­ly­sis.
  • Very good inter­per­so­nal and com­mu­ni­ca­tion skills; in par­ti­cu­lar, the abi­lity to effec­tively work in a diverse, col­la­bo­ra­tive and inter­di­sci­pli­nary rese­arch envi­ron­ment.
  • Flu­ency in Eng­lish - writ­ten and oral. (Ger­man is not requi­red).

What we offer:

The BIO­TEC/CMCB is a renow­ned inter­di­sci­pli­nary and inter­na­tio­nal rese­arch insti­tute of the TU Dres­den that boasts a col­la­bo­ra­tive spi­rit and cut­ting-edge tech­no­logy plat­forms, inclu­ding one of the natio­nal genome cen­tres and cut­ting-edge High Per­for­mance Com­pu­ting resour­ces. The city of Dres­den and the DFG focus pro­gram (Genome3) pro­vide nume­rous oppor­tu­nities for sci­en­ti­fic exchange and col­la­bo­ra­tion.

How to apply:

TUD stri­ves to employ more women in aca­de­mia and rese­arch. We the­re­fore expressly encou­rage women to apply. The Uni­ver­sity is a cer­ti­fied family-fri­endly uni­ver­sity and offers a Dual Career Ser­vice. We wel­come app­li­ca­ti­ons from can­di­da­tes with disa­bi­li­ties. If mul­ti­ple can­di­da­tes prove to be equally qua­li­fied, those with disa­bi­li­ties or with equi­va­lent sta­tus pur­suant to the Ger­man Social Code IX (SGB IX) will receive prio­rity for employ­ment.
Please sub­mit your com­pre­hen­sive app­li­ca­tion inclu­ding the usual docu­ments, inclu­ding a let­ter of moti­va­tion, your CV inclu­ding a list of publi­ca­ti­ons, tran­scripts of records, and con­tact details for 2-3 aca­de­mic refe­ren­ces, by Decem­ber 15, 2022 stam­ped arri­val date of the uni­ver­sity cen­tral mail ser­vice app­lies) pre­fer­a­bly via the TU Dres­den Secu­re­Mail Por­tal https://securemail.tu-dresden.de by sen­ding it as a sin­gle pdf docu­ment to sabine.zeissig@tu-dresden.de, alter­na­tively via mail to: TU Dres­den, BIO­TEC, For­schungs­gruppe Bio­me­di­zi­ni­sche Geno­mik, Frau Dr. Anna Poe­tsch, Helm­holtz­str. 10, 01069 Dres­den, Ger­many. Please sub­mit copies only, as your app­li­ca­tion will not be retur­ned to you. Expen­ses incur­red in atten­ding inter­views can­not be reim­bur­sed.

Refe­rence to data pro­tec­tion: Your data pro­tec­tion rights, the pur­pose for which your data will be pro­ces­sed, as well as fur­ther infor­ma­tion about data pro­tec­tion is avail­able to you on the web­site: https://tu-dresden.de/karriere/datenschutzhinweis.