Charité - Universitätsmedizin Berlin - Berlin-Oxford Centre for Advanced Studies
Die Charité - Universitätsmedizin Berlin ist eine gemeinsame Einrichtung der Freien Universität Berlin und der Humboldt-Universität zu Berlin. Sie hat als eines der größten Universitätsklinika Europas mit bedeutender Geschichte eine führende Rolle in Forschung, Lehre und Krankenversorgung inne. Aber auch als modernes Unternehmen mit Zertifizierungen im medizinischen, klinischen und im Management-Bereich tritt die Charité hervor
Postdoctoral Scientist - Microbiology, Systems Biology, Functional Omics
CC02, Department für Biochemie | Charité Campus Mitte
Brief description of field of application
Located in the heart of Berlin, Charité – Universitätsmedizin Berlin is one of Europe's largest and most research-intensive medical universities. The present position is a postdoctoral project that addresses the role of bacterial-fungal co-infections in the evolution of antimicrobial resistance. This is a joint project between the group of Markus Ralser (Director of Institute of Biochemistry) and research at the University of Oxford, headed by Craig MacLean and Rachel Wheatley. This project is funded through the Berlin University Alliance and part of the Ox|Ber Oxford/Berlin Research Partnership. We are leaders in microbiology and metabolism research, employing large-scale, ultra-fast proteomics and evolutionary genomics to investigate antimicrobial resistance and tolerance mechanisms in bacterial and fungal pathogens.
We are looking for a highly enthusiastic postdoctoral scientist to investigate the role of bacterial-fungal co-infections in the evolution of antimicrobial resistance (AMR), with particular focus on the multi-drug resistant bacterium Pseudomonas aeruginosa (PA) and the opportunistic fungal pathogen Candida albicans (CA). This position will be formally based at the Charité in Berlin, but will conduct part of the project at the University of Oxford.
Your main tasks will be:
Adapting existing and developing improved experimental protocols for the high-throughput analysis of AMR in a CA-PA co-infection model
Determining the underlying mechanisms that alter stress tolerance in a CA-PA co-infection model;
Performing Adaptive Laboratory Evolution (ALE) and high-throughput proteomics experiments to monitor the emergence of tolerance and resistance in CA-PA communities;
Identifying synergistic mechanisms that enable co-infecting pathogens to establish persistent communities and lead to worse patient outcomes;
Promoting and fostering awareness about co-infections and their role in AMR emergence;
Lead and support the preparation of scientific reports and journal articles.
You will get access to:
State-of-the-art research equipment and highly international and collaborative environments both at the Charité - Universitätsmedizin Berlin and University of Oxford;
Extended stays at each academic institution;
Opportunity to work in close contact with other basic- and clinical-research groups at Charité in the heart of Germany's vibrant capital;
Opportunity to work in close contact with other research groups within the Department of Zoology at the University of Oxford, one of the world's leading research universities;
Potential to lead multiple projects and a high degree of academic freedom
PhD/Doktorgrad or equivalent in natural sciences (Biological Sciences, Microbiology, Biochemistry, Systems Biology, Molecular Biology, Bioinformatics/Computational Biology, or related fields)
Experience of designing and running experiments with microbial cultures (bacteria and/or fungi) in the laboratory
Hands-on experience with key biochemical and molecular biological methods
Experience with systems biology projects, high-throughput methodologies
Experience with analytical and omics methods (LC-MS, NGS)
Basic ability to analyse data in R or Python
Good communication skills for collaborative work
Any of the following will be a plus:
Proficiency in data analysis using R
Interest in multispecies communities, host-pathogen interactions, or related topics
How to apply:
Working language is English. Applicants with multidisciplinary background or unusual career paths are also encouraged to apply.