Blätter-Navigation

Of­fer 320 out of 646 from 10/09/21, 11:22

logo

Helm­holtz-Zen­trum für Infek­ti­ons­for­schung GmbH - Infek­ti­ons­for­schung

Das Helm­holtz-Zen­trum für Infek­ti­ons­for­schung (HZI) in Braun­schweig ist eine For­schungs­ein­rich­tung des Bun­des und des Lan­des Nie­der­sach­sen inner­halb der Helm­holtz-Gemein­schaft, der größ­ten Wis­sen­schafts­or­ga­ni­sa­tion Deutsch­lands.

Doc­toral Researcher (f/m/d) - SARS-CoV2 drug dis­cov­ery

English

The Insti­tute for Exper­i­mental Vir­o­logy, led by Prof. Dr. Thomas Pietschmann at TWIN­CORE - Cen­ter for Exper­i­mental and Clin­ical Infec­tion Research in Han­over, is offer­ing a pos­i­tion as Doc­toral Researcher (f/m/d) - SARS-CoV2 drug dis­cov­ery to sup­port our inter­na­tional and inter­dis­cip­lin­ary team.

Work­ing field:

The Insti­tute for Exper­i­mental Vir­o­logy, led by Prof. Dr. Thomas Pietschmann at TWIN­CORE - Cen­ter for Exper­i­mental and Clin­ical Infec­tion Research in Han­over, is offer­ing a pos­i­tion as Doc­toral Researcher (f/m/d) - SARS-CoV2 drug dis­cov­ery to sup­port our inter­na­tional and inter­dis­cip­lin­ary team.

Pro­ject descrip­tion:
At TWIN­CORE med­ical per­son­nel and basic research sci­ent­ists from vari­ous dis­cip­lines con­duct infec­tion research side by side. Our focus is upon trans­la­tional research the inter­face between basic research and clin­ical devel­op­ment. Since the onset of the COVID19 pan­demic, WHO data report that there have been 207,000,000 con­firmed cases and 4,400,000 deaths asso­ci­ated to SAR-CoV-2. In the face of effect­ive vac­cine devel­op­ment and ongo­ing tri­als of new vac­cines, addi­tional options are needed to be added to our arsenal to counter the pan­demic.

One of these is the devel­op­ment of anti­vir­als that act against coronavir­uses. Ideally, these inhib­it­ors will have the abil­ity to act broadly to counter the spread­ing of dif­fer­ent vir­uses belong­ing to the coronavirus fam­ily.

The suc­cess­ful can­did­ate will screen for molecules with anti­viral activ­ity against coronavirus enzymes work­ing closely with mul­tiple insti­tutes at Helm­holtz Centre for Infec­tion Research (HZI) and in col­lab­or­a­tion with med­ical chem­ists, vir­o­lo­gists and bio­chem­ists. Using advanced com­pound mod­el­ing algorithms and cel­lu­lar and bio­chem­ical meth­ods she/he/d will identify can­did­ates that demon­strate ini­tial anti­viral activ­ity. Sub­sequently, the most prom­ising com­pounds will be optim­ized to increase their anti­viral activ­ity. She/he/d will be respons­ible for the vir­o­lo­gical pro­fil­ing of com­pounds in cell cul­tures up to ana­lysis in primary cell lines, the val­id­a­tion of bio­lo­gical tar­get, the molecu­lar char­ac­ter­iz­a­tion of the mode of action and mech­an­isms of res­ist­ance and for the devel­op­ment of phen­o­typic assays for com­pound optim­iz­a­tion.

Require­ments:

Qual­i­fic­a­tions:
  • Mas­ter’s degree in life sci­ences (Vir­o­logy, immun­o­logy, cell bio­logy, bio­chem­istry).
  • Strong hands on exper­i­ence in labor­at­ory tech­niques and molecu­lar meth­ods.
  • Gen­eral under­stand­ing of the bio­chem­ical inter­ac­tions involved in host-patho­gen inter­play.
  • Abil­ity to pay atten­tion to detail, pur­sue research inde­pend­ently and work in a goal-ori­ented man­ner.
  • Will­ing­ness to work in a plural, col­legial, inter­na­tional and inter­dis­cip­lin­ary envir­on­ment.
  • Flu­ency in Eng­lish lan­guage (writ­ten and spoken)

Advant­age­ous for this pos­i­tion (con­tin­gent pos­i­tion):
  • Pre­vi­ous exper­i­ence in the field of RNA vir­o­logy.
  • Exper­i­ence with cell cul­ture and cul­tiv­a­tion of primary cell lines.
  • Expert­ise in next gen­er­a­tion sequen­cing tech­niques

Dis­abled per­sons are given pref­er­ence in the case of equal pro­fes­sional qual­i­fic­a­tion. The HZI aims for pro­fes­sional equal­ity between all genders.

What we of­fer:

  • Mod­ern labor­at­or­ies
  • State-of-the-art ana­lyt­ical instru­ment­a­tion
  • Ample bio­lo­gical pro­fil­ing plat­forms (in vitro and in vivo)
  • The oppor­tun­ity to enroll in a struc­tured PhD pro­gramme at HZI or at the Han­nover Med­ical School (MHH)
  • A lively sci­entific com­munity
  • 30 days vaca­tion
  • An annual addi­tional pay­ment (Weih­nachts­geld) ana­logue to § 20 TVöD
  • Social secur­ity included
  • DO IT- PhD ini­ti­at­ive https://www.helmholtz-hzi.de/de/karriere/do-it-doktorandeninitiative
  • Wel­come Office
  • Buddy sys­tem
  • Fam­ily Office

How to ap­ply:

Applic­ants are required to com­plete the online applic­a­tion form here:
https://hzi.opencampus.net/ (Please select Job No. 138/2021).