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Max Planck Insti­tute of Col­loids and Inter­faces - Depart­ment of Bio­ma­ter­i­als

The Depart­ment of Bio­ma­ter­i­als focuses on inter­dis­cip­lin­ary research in the field of bio­lo­gical and bio­mi­metic mater­i­als. The emphasis is on under­stand­ing how the mech­an­ical or other phys­ical prop­er­ties are gov­erned by struc­ture and com­pos­i­tion and how they adopt to envir­on­men­tal con­di­tions.

MSc thesis: The effect of mul­tiple myel­oma pro­gres­sion in bone extra­cel­lu­lar mat­rix

English

Mas­ter thesis at the Max Planck Insti­tute of Col­loids and Inter­faces

Work­ing field:

Back­ground: Bio­tech­no­logy, Bio­med­ical Engin­eer­ing, Mater­i­als Sci­ence, Bio­medi­cine, Bio­logy or sim­ilar

Require­ments:

You should have a back­ground in bio­tech­no­logy, bio­med­ical engin­eer­ing, bio­medi­cine, bio­logy or sim­ilar, and strong interest in can­cer bio­logy. The pro­ject will be car­ried out at the Max Planck Insti­tute of Col­loids and Inter­faces in the group of Dr Amaia Cipitria together with Dr Inés Moreno. This pro­ject is part of a col­lab­or­a­tion with the onco­lo­gist Prof. Dr. med. Fran­ziska Jundt, Uni­versität­sk­linikum Würzburg.

What we of­fer:

Mul­tiple myel­oma (MM) is a type of blood can­cer in which plasma cells grow aber­rantly and pro­duce abnor­mal anti­bod­ies. In the clinic, MM patients show lesions in the skel­eton that do not heal, even when the patient is in com­plete remis­sion. MM cells mainly reside in the bone mar­row and alter bone homeo­stasis by activ­at­ing bone resorp­tion and inhib­it­ing bone form­a­tion. We are inter­ested in under­stand­ing how these can­cer cells alter the prop­er­ties of the bone extra­cel­lu­lar mat­rix at dif­fer­ent stages of dis­ease pro­gres­sion.

The pro­ject will involve doc­u­ment­a­tion and ana­lysis of human bone biopsies col­lec­ted from patients who present sev­eral stages of this type of blood can­cer. The ana­lysis of these bone biopsies will be based in his­to­logy, immun­o­his­to­chem­istry, histo­morpho­metry, con­focal and elec­tron micro­scopy. Explor­at­ory ana­lysis will involve immun­o­his­to­chem­istry to loc­al­ize can­cer cells in the tis­sue, his­to­logy and histo­morpho­metry to char­ac­ter­ize bone tis­sue com­pos­i­tion, and con­focal and elec­tron micro­scopy to eval­u­ate changes in the bone micro­struc­ture.

How to ap­ply:

Please send your applic­a­tion includ­ing a motiv­a­tion let­ter, your CV and a tran­script of your uni­versity record to these two email addresses: ines.moreno@mpikg.mpg.de and amaia.cipitria@mpikg.mpg.de. Please indic­ate “Mas­ter thesis – bone extra­cel­lu­lar mat­rix mul­tiple myel­oma” in the sub­ject line. The pro­ject can start at the begin­ning of July 2020. The work­ing lan­guage is Eng­lish.