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An­ge­bot 182 von 377 vom 02.08.2017, 11:11

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Robert Koch-Insti­tut - Robert Koch-Insti­tute, Nachwuchs­gruppe 2

The junior rese­arch group 2 uti­li­zes mass spec­tro­me­try and micro­scopy-based approa­ches to inves­ti­gate the meta­bo­lism of pro­to­zoan patho­gens, with a strong focus on Toxo­plasma gon­dii. In par­ti­cu­lar we are inte­rested in per­sis­tent sta­ges of the para­site.

Die Nach­wuchs­gruppe 2 benutzt mas­sen­spek­tro­me­tri­sche und mikro­sko­pi­sche Metho­den um den Stoff­wech­sel von patho­gene Mikro­ben, ins­be­son­dere Toxo­plasma gon­dii's zu unter­su­chen. Von spe­zi­el­lem Inter­esse sind dabei per­sis­tente Sta­dien.

2 PhD pos­i­tions in para­site meta­bolo­m­ics

We are offer­ing two PhD pos­i­tions in para­site meta­bolo­m­ics to start at the earli­est pos­sible date.

Work­ing field:

Chronic infec­tions with bac­terial, fungal and para­site patho­gens that evade cur­rent med­ical treat­ments are a mount­ing prob­lem for the pub­lic health. Tox­o­plasma gondii causes untreata-ble chronic infec­tions in 30% of humans world-wide. We use this pro­to­zoan as a model to in-vestig­ate meta­bolic mech­an­isms that enable per­sist­ence and to identify novel inter­ven­tion strategies.
We are devel­op­ing state-of-the-art meta­bolo­m­ics plat­form (LCMS and GCMS) for global and untar­geted ana­lysis of para­site meta­bol­ism. These mass spec­tro­metry-based approaches are com­ple­men­ted with single cell-resolved micro­scopic ana­lyses and reverse-genetic meth­ods.

  • In vitro cul­tiv­a­tion of T. gondii para­sites and reverse genetic manip­u­la­tion of T. gondii para-sites (CRISPR, knock-out, knock-in)
  • mass spec­tro­metry-based ana­lysis of meta­bol­ites (untar­geted LCMS und tar­geted GCMS)
  • Life - cell ima­ging, molecu­lar bio­logy meth­ods
  • Pub­lic­a­tion and present­a­tion of research res­ults

Require­ments:

A com­pleted uni­versity degree (Mas­ters, Dip­loma, Hon­ours) in the field of life sci­ences, prefer­ably bio­logy, bio­chem­istry, bio­tech­no­logy or bio­phys­ics, which qual­i­fies you to com­plete a PhD
  • Pre­vi­ous expos­ure to mass spec­tro­metry, life - cell ima­ging with respect­ive data ana­lysis meth­ods and molecu­lar bio­lo­gical meth­ods are advant­age­ous
  • Solid skills in MS-Office applic­a­tions or equi­val­ent are required; know­ledge in R und Python are wel­comed
  • Required lan­guage skills (CEFR-level): advanced know­ledge of Eng­lish (at least C1). Although no Ger­man skills are required, applic­ants will be encour­aged to develop such skills to maxim-ize their integ­ra­tion in our insti­tute.

You should have a proven interest in meta­bol­ism. You are also able to inde­pend­ently for­mu­late sci­entific ques­tions and develop exper­i­mental approaches. You have the abil­ity to quickly take up new tasks and work inde­pend­ently with appro­pri­ate super­vi­sion to meet object­ives. You’re open-minded and seize oppor­tun­it­ies to net­work within and out­side the insti­tute.

What we of­fer:

We are offer­ing the fol­low­ing pos­i­tions in our Junior Research Group 2 for two
Doc­toral Can­did­ates (PhD pos­i­tions m/f, 50 %, pub­lic sec­tor wage scale TVöD grade 13)
for a fixed term of two years with the option of exten­sion for a third year, start­ing at the earli­est pos­sible oppor­tun­ity. The pos­i­tion is part-time to allow an oppor­tun­ity for inde­pend­ent research ded­ic­ated to comple-tion of doc­toral work. Ber­lin offers a wide range of PhD pro­grams provid­ing weekly talks by inter­na­tional speak­ers and many oppor­tun­it­ies to inter­act with fel­low stu­dents. Pos­i­tions are equipped with travel funds and one stu­dent research assist­ant each.

How to ap­ply:

Sub­mit your applic­a­tion via the pub­lic ser­vice job portal Interamt at www.interamt.de by 7. August 2017. Please note the pos­i­tion iden­ti­fic­a­tion num­ber: 397506 (Stel­lenID)/ Kz. 78/17.
If you have ques­tions about the applic­a­tion pro­ced­ure, please con­tact Kath­ar­ina Brandt (Tel.: +49 30 18754 2812 E-Mail: BrandtK[at]rki.de) and the Junior group leader Dr. Mar­tin Blume (+49 30 18754 2572 blumem[at]rki.de).